Ailments
Resistance Shred
Each damage type (Physical, Cold, Fire, Lightning, Necrotic, Poison and Void) has a respective Resistance Shred ailment, such as Fire Resistance Shred.
Resistance Shred ailments reduce the target's resistance for that particular damage type. They subtract 5% resistance against most enemies, but only 2% against players and bosses. They last 4 seconds by default and stack up to 10 times.
Like penetration, resistance shred can bring effective resistance below 0%, further increasing damage taken. Most enemies have 0% resistance, so 10 stacks of Fire Resistance Shred will result in them having -50% Fire Resistance and consequently taking 50% more fire damage.